Molecular Biomarkers & Diagnosis

Ping L Zhang

Publications

• Research Article
  Diagnostic Values of a Progenitor Cell Marker CD133 Expression in Various Types of Adenocarcinoma
  Author(s): Kevin J Zhang, Satyum R Parikh, Nava Sigelmann-Danieli, Jason M Hafron, James L Liu, John D Schwartz, Mitual B Amin, Zhenhong Qu and Ping L ZhangKevin J Zhang, Satyum R Parikh, Nava Sigelmann-Danieli, Jason M Hafron, James L Liu, John D Schwartz, Mitual B Amin, Zhenhong Qu and Ping L Zhang
  
  Background: The role of stem tumor cell involvement in tumorigenesis and partial resistance to chemotherapy has been established in recent years. However, diagnostic value using stem cell markers in various malignant neoplasms is not well addressed. In the current study, we compared CD133, a membranous stem cell marker, in several types of adenocarcinoma originating in colon, breast and kidney tissues, in order to determine whether expression pattern may be useful for diagnosis and differential diagnosis of varying tumors. Methods: Paraffin embedded control and tumor sections (35 from colon, 40 from breast and 64 from kidneys) were immunohistochemically stained for CD133 using an autostainer. All membranous stains of CD133 were graded from negative (0) to 3+. Results: In the colon, benign glands showed minimal stai.. Read More»
  DOI: 10.4172/2155-9929.1000299

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