Molecular Biomarkers & Diagnosis

Piti Ungarreevittaya

Publications

• Research Article
  Prognostic Role of RANK and RANKL Expression in Recurrent Giant Cell Tumor of Bone: A Retrospective Study
  
  Author(s): Nannaphat Atsawaphidsawat, Piti Ungarreevittaya and Chat SumananontNannaphat Atsawaphidsawat, Piti Ungarreevittaya and Chat Sumananont
  
  Objective: Giant cell tumor of bone (GCTB) is a benign locally aggressive primary bone tumor with a tendency for recurrence which is one of the major problems in this disease. Recent data demonstrated the important role of the receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) pathway in the pathogenesis. However, the roles of RANK and RANKL in predicting recurrence have never been proposed. Therefore, we aim to investigate the prognostic value of RANK and RANKL expression in predicting recurrence of GCTB which may change the treatment paradigm of the disease. Method: 53 cases of GCTB were enrolled in the study. Data on patient demographics and clinical characteristics were reviewed. Immunohistochemistry was used to detect the expression of RANK and RANKL. Recurrence-free survival (RFS) analysis was performed by Kaplan–Meier method and the difference between s.. Read More»
  DOI: 10.4172/21559929.1000394

  Abstract