Cancer Science & Therapy

PK Julka

Publications

• Research Article
  Impact of MDM2 SNP309T>G Polymorphism: Increased Risk of Developing Non Small Cell Lung Cancer and Poor Prognosis in Indian Patients
  Author(s): Jamsheed Javid, Rashid Mir, M Masroor, Shazia Farooq, Imtiyaz Ahamad, Prasant Yadav, Maryam Zubari, PC Ray, Ajaz Ah Bhat, PK Julka, Anant Mohan, Maqbool Lone, MA Banday and Alpana SaxenaJamsheed Javid, Rashid Mir, M Masroor, Shazia Farooq, Imtiyaz Ahamad, Prasant Yadav, Maryam Zubari, PC Ray, Ajaz Ah Bhat, PK Julka, Anant Mohan, Maqbool Lone, MA Banday and Alpana Saxena
  
  Background: MDM2 is an important negative regulator of the TP53 pathway, over expressed in many cancers as oncoprotein. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus play an important role in carcinogenesis.   Aim and methods: To test our hypothesis that the MDM2 promoter polymorphisms are associated with risk of non small cell lung cancer, we conducted a hospital-based, case–control study of 136 Indian patients diagnosed with NSCLC and 136 cancer-free controls and investigated the association between genetic variation in the promoter region of MDM2 (c.–51309G4T, rs2279744:g.G4T) and the risk of developing NSCLC by tetra-primer ARMS-PCR and ASO-PCR.   Results: Compared with the MDM2-2580TT genotype, we found that the MDM.. Read More»
  DOI: 10.4172/1948-5956.1000165

  Abstract PDF