Journal of Dermatology and Dermatologic Diseases

PK Nigam

Publications

• Review Article
  Premature Greying of Hair (Premature Canities): A Concern for Parent and Child
  Author(s): PK Nigam and Pallavi NigamPK Nigam and Pallavi Nigam
  
  Hair goes grey with chronological aging. Premature hair greying may have significant adverse effects on the appearance, self-esteem, and socio-cultural acceptance of the affected individual. The exact aetiopathogenetic mechanism causing premature greying is still not clear and much speculative. Premature canities may appear alone as an autosomal dominant trait or it may occur in association with certain other disorders. The genes Pax3 and MITE play an important role in melanocyte stem cell maintenance and differentiation. Defective melanosomal transfer to the cortical keratinocytes or melanin incontinence due to melanocyte degeneration is also believed to contribute to greying. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, treatment options still remain far from satisfactory and no effective therapy is available. Premature greyi.. Read More»
  DOI: 10.4172/2376-0427.1000260

  Abstract PDF