Journal of Bioanalysis & Biomedicine

Pornlada Nuchnoi

Publications

• Research Article
  The Identification of Functional Non-Synonymous SNP in Human ATPBinding Cassette (ABC), Subfamily Member 7 Gene: Application of Bioinformatics Tools in Biomedicine
  Author(s): Pornlada Nuchnoi, Duangdao Nantakomol, Vasunun Chumchua, Chotiros Plabplueng, Chartchalerm Isarankura-Na-Ayudhya and Virapong PrachayasittikulPornlada Nuchnoi, Duangdao Nantakomol, Vasunun Chumchua, Chotiros Plabplueng, Chartchalerm Isarankura-Na-Ayudhya and Virapong Prachayasittikul
  
  The prediction of functional single nucleotide polymorphism (SNP) is promising in modern genetics analysis. Computational biology technology has facilitated an increase in the successful rate of genetic association study and reduced the cost of genotyping. In the present study, we applied various bioinformatics tools for the selection of high potentially functional nsSNP and determined the linkage disequilibrium (LD) structure of ATP-binding cassette transporter member 7 (ABCA7) genes in HapMap populations. Two functional polymorphisms (rs3752233 and rs3752246) were identified on the basis of less protein stability, a low likelihood of mutability, a changing of protein structure and function. Interestingly, a completed LD between rs3752233 (R463H) and rs4147918 (Q1686R) was detected in Utah residents with ancestry from northern and western Europe (CEU) populations. In addition, the di.. Read More»
  DOI: 10.4172/1948-593X.1000039

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