Journal of Computer Science & Systems Biology

Pradeep Das

Publications

• Research Article
  Structural Modeling, Evolution and Ligand Interaction of KMP11 Protein of Different Leishmania Strains
  Author(s): Ganesh Chandra Sahoo, Mukta Rani, Manas Ranjan Dikhit, Waquar Akhtar Ansari and Pradeep DasGanesh Chandra Sahoo, Mukta Rani, Manas Ranjan Dikhit, Waquar Akhtar Ansari and Pradeep Das
  
  The kinetoplastid-specific KMP11 protein was first described for Leishmania donovani associated with the lypophosphoglycan molecule and is localized mainly around the flagellum and flagellar pocket. This protein is well conserved among kinetoplastids and plays an analogous role in all the flagellates, irrespective of their pathogenicity in humans. The structural elucidation of this important protein may bring about information required to target KMP11 to find valid drug candidates. The atomic-resolution model of KMP11 protein of six different Leishmania strains has been determined from its amino acid sequence by using homology modeling. The stereochemical validation of modeled protein has been done by PROCHECK and Profiles-3D scores. The ligand protein interaction of the KMP11 protein models were carried out with several anti-leishmanial drugs i.e. miltefo.. Read More»
  DOI: 10.4172/jcsb.1000026

  Abstract PDF