Pharmaceutical Regulatory Affairs: Open Access

Prafulla Kumar Sahu

Publications

• Research Article
  Stress Testing of Quetiapine Fumarate by a Chemometric Assisted Multi-Component Ion-Interaction System
  Author(s): Suryakanta Swain and Prafulla Kumar SahuSuryakanta Swain and Prafulla Kumar Sahu
  
  Classical experimental designs have been popularly employed in establishing robust analytical methods while achieving other advantages, viz., reduction in the number of experiments and hence lower reagent consumption and less laboratory work. To achieve optimum chromatographic condition, a computer-aided Box-Behnken Design (BBD) in ion-pairing stability-indicating RP-HPLC assay of quetiapinefumarate along with its stress related substances has been investigated here, proving to be an invaluable tool in ascertaining a reliable method. The study includes forced degradation of quetiapinefumarateunder acidic, alkaline, photo, oxidative and peroxide stress condit.. Read More»
  DOI: 10.4172/2167-7689.1000188

  Abstract PDF