Molecular Biomarkers & Diagnosis

Prathima R

Publications

• Research Article
  Assessment of Ki67 As a Prognostic Marker in Hormone Receptor Positive Breast Cancer: A Retrospective Study on An Indian Cohort
  Author(s): Charusheila Ramkumar, Chandra Prakash, Lekshmi Madhav, Arun Kumar, Chetana Basavaraj, Prathima R, Nirupama Naidu and Manjiri M BakreCharusheila Ramkumar, Chandra Prakash, Lekshmi Madhav, Arun Kumar, Chetana Basavaraj, Prathima R, Nirupama Naidu and Manjiri M Bakre
  
  The prognostic utility of the proliferation marker Ki67 to decide breast cancer treatment has been widely investigated and continues to be a source of much controversy. In this study, we evaluated: i) the role of Ki67 as a prognostic and predictive tool in patients with hormone receptor positive (ER+/PR+) carcinoma of the breast and ii) analyzed its correlation with two commonly used clinicopathological parameters, viz node status and tumor grade to predict clinical outcomes. To determine the clinical utility of Ki67 in assessment of breast cancer prognosis, we examined its expression by immunohistochemistry (IHC) in a series of 160 hormone receptor positive patients in a retrospective cohort of Indian patients. Patients were stratified based on Ki67 expression and analyzed for 5-year distant metastasis free survival (DMFS). Amongst the baseline clinicopathologic variables, we found n.. Read More»
  DOI: 10.4172/2155-9929.1000336

  Abstract PDF