Journal of Cytology & Histology

Pratibha R Kamble

Publications

• Research Article
  Cisplatin Induced Histological and Ultrastructural Alterations In Liver Tissue of Rat
  Author(s): Pratibha R Kamble and Dayanand A BhiwgadePratibha R Kamble and Dayanand A Bhiwgade
  
  Background: Cisplatin is well-known anticancer drug often been used for treatment of various human malignancies. The hepatotoxic or nephrotoxic effect of drug is a result of altered histological and antioxidant status of the organ. In order to document the extent of cisplatin (CDDP) effect on liver we have studied long term treatment of cisplatin (CDDP) to rat. In our previous studies we have demonstrated changes in reduced glutathione (GSH) and glutathione related enzymes of liver followed by increased lipid peroxidation process. Materials: Light microscopy (LM) was carried out in liver tissue by haematoxylin and eosin staining. Electron microscopy was performed by staining with uranil acetate and lead citrate. Results: Recent reports depicts that CDDP treatment caused significant alteration at histopathological level showing increased vacuolation in hepatocytes. A noticeable cha.. Read More»
  DOI: 10.4172/2157-7099.1000128

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