Consultant in Haemoglobinopathy (Thalassaemiology),
India
Research Article
Correlation of Serum Ferritin with Hepatic Iron Overload among Nontransfusion Dependent Beta Thalassaemia with Haemoglobin E Disease Patients from Eastern India
Author(s): Prosanto Chowdhury, Manash Saha and Dhritidipa ChowdhuryProsanto Chowdhury, Manash Saha and Dhritidipa Chowdhury
Introduction: Iron over load estimation was attempted by MRI R2* and serum ferritin, in non -transfusion dependent HbE Beta Thalassaemia patients.
Methods: Seventy three patients selected on definite criteria were scanned and tested. Average age of the patients was 20.8 ± 11.14 years, 33 females and 40 male. Average hepatic iron concentration was determined to be 11.09 ± 11.74 mg/g of dry liver tissue and average serum ferritin was 972.44 ± 1121.51 ng/ml.
Results: 81% of the patients had hepatic iron concentration more than 2 mg/g of dry liver tissue, whereas only 41% had serum ferritin level >500 ng/ml, irrespective of age. The hepatic iron overload pattern was heterogenous, where age and sex were not well determined variable predictors of such iron overload. Though, hi.. Read More»
DOI:
10.4172/2155-9929.1000231
Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report