Pulmonary & Respiratory Medicine

Pulin Shah

Publications

• Research Article
  Trimethoprim-Sulfamethoxazole (TMP-SMX) Induced Severe Systemic Reaction
  Author(s): Farrukh Abbas, Mehul Patel, Khuram Abbas, Pulin Shah and Michael N GurelFarrukh Abbas, Mehul Patel, Khuram Abbas, Pulin Shah and Michael N Gurel
  
  Objective: Trimethoprim-Sulfamethoxazole (TMP-SMX) is a relatively commonly prescribed antibiotic. One of the rare but dramatic reactions to TMP-SMX is severe systemic reaction which can mimic sepsis or septic shock and this can be a diagnostic challenge especially in critical care setting. The objective is to raise information about this side effect. Study Selection: The case series includes two patients’ reports. The first patient was 85 year old woman who received TMP-SMX before dental extraction and presented with rash and fever. She met SIRS criteria with leukocytosis, bandemia, lactic acidosis and acute kidney injury. All the infectious work remained negative. She improved with supportive care. She received TMP-SMX again after a few weeks and again presented with similar clinical course. Again the infectious work up remained negative and she improved with supportive care. .. Read More»
  DOI: 10.4172/2161-105X.1000393

  Abstract PDF