Journal of Trauma & Treatment

Pullen Shnoda

Publications

• Research Article
  A Comparison of Hemostatic Effectiveness and Safety of Two Fibrin Sealant Patch Products after Severe Renal Hemorrhage in Swine Model of Dilutional and Hypothermic Coagulopathy
  
  Author(s): Richard W. Hutchinson, Pullen Shnoda, Scott T. Wilson and Ira W. DalyRichard W. Hutchinson, Pullen Shnoda, Scott T. Wilson and Ira W. Daly
  
  Background: Two fibrin sealant patch products (EVARREST™ and TachoSil™) are approved by the USFDA for use in surgical settings. While these products are among the most likely to be useful for trauma use, they are not approved for this use. There is a clinical need for trauma hemostats. Methods: A well characterized animal model for severe soft tissue hemorrhage (partial nephrectomy) was combined with another well characterized model for dilutional and hypothermic coagulopathy. The two fibrin sealant patch materials available in the US were each applied to 12 animals. Animal assignment was randomized. If hemostasis could be achieved, the animals were resuscitated and survived for 48 hours. Results: TachoSil™ was able to achieve hemostasis in 2 of 12 animals which survived to the scheduled necropsy date without significant pathology. For the two suc.. Read More»
  

  Abstract