Journal of Biometrics & Biostatistics

Quanlin-Li

Publications

• Research Article
  Dose Finding for Drug Combination in Early Cancer Phase I Trials Using Conditional Continual Reassessment Method
  Author(s): Márcio Augusto Diniz, Quanlin-Li and Mourad TighiouartMárcio Augusto Diniz, Quanlin-Li and Mourad Tighiouart
  
  We describe a dose escalation algorithm for drug combinations in cancer phase I clinical trials. Parametric models for describing the association between the doses and the probability of dose limiting toxicity are used assuming univariate monotonicity of the dose-toxicity relationship. Trial design proceeds using the continual reassessment method, where at each stage of the trial, we seek the dose of one agent with estimated probability of toxicity closest to a target probability of toxicity given the current dose of the other agent. A Bayes estimate of the maximum tolerated dose (MTD) curve is proposed at the conclusion of the trial for continuous doses or a set of MTDs is determined in the case of discrete dose levels. We evaluate design operating characteristics in terms of safety of the trial and percent of dose recommendation at dose combination neighborhoods around the true MTD .. Read More»
  DOI: 10.4172/2155-6180.1000381

  Abstract PDF