Pulmonary & Respiratory Medicine

R Stern

Publications

• Review Article
  Hyaluronidase: A Potential New Treatment for Acute Respiratory Distress Syndrome
  Author(s): C LeBlanc and R SternC LeBlanc and R Stern
  
  Acute respiratory distress syndrome, also known as diffuse alveolar damage, is an acute injury to the lungs. Patients experience severe shortness of breath and require mechanical ventilation. It is not a specific disease, but an acute lung dysfunction associated with a variety of disorders: pneumonia, shock, sepsis, and trauma. A similar lesion occurs in newborn infants, called hyaline disease of the newborn. It occurs in premature babies and has the same pathophysiological mechanism as acute respiratory distress syndrome. Hyaline membranes are a pathologic feature of acute respiratory distress syndrome, consisting of basophilic structures that coat alveolar surfaces. They prevent oxygen exchange and are the basis of the lethality of this disorder. The syndrome is associated with very high levels of hyaluronan in broncho-alveolar lavage specimens. We postulate that the hyaline membran.. Read More»
  DOI: 10.4172/2161-105X.1000407

  Abstract PDF