Journal of Cytology & Histology

Rafik Gharbi

Publications

• Research Article
  Effect of Chronic Administration of Aluminum Trichloride on Testis among Adult Albino Wistar Rats
  Author(s): Nadia Hichem, Michèle El May, Nizar Laadhari, Ali Mrabet and Rafik GharbiNadia Hichem, Michèle El May, Nizar Laadhari, Ali Mrabet and Rafik Gharbi
  
  Different forms of Aluminum are environmental xenobiotics that induce free radical-mediated cytotoxicity and reproductive toxicity. We studied the aluminum trichloride (AlCl3) toxicity on adult rat testes. Male Wistar rats were treated orally with AlCl3 at three doses: 100, 200 and 400 mg/kg bw for 6, 12 and 18 months. Body and testes weight were followed. Plasma and testicular metal levels were assayed by atomic absorption spectrophotometry with graphic oven method. Light microscopy observation of testes was also performed. The results showed a significant decrease (p<0.05) of body weight only at 18 months with the highest dose compared to the control group. We also noted a decrease in testicular weight in all treated groups at 12 and 18 months and only for the group treated with 400 mg/kg bw at 6 months. Aluminum trichloride resulted in a significant increase (p<.. Read More»
  DOI: 10.4172/2157-7099.1000195

  Abstract PDF