Journal of Computer Science & Systems Biology

Raghuvir Singh

Publications

• Research Article
  In silico Analysis Metabolic Pathways for Identification of Putative Drug Targets for Staphylococcus aureus
  Author(s): V. K. Morya, Varun Dewaker, S. D. Mecarty and Raghuvir SinghV. K. Morya, Varun Dewaker, S. D. Mecarty and Raghuvir Singh
  
  Staphylococcus aureus is one of the most important and studied gram positive bacterial strains, which have a great potential to infect human beings as well as other mammals. The hospital-acquired methicillin-resistant, vancomycinsusceptible gram–positive bacteria strain is responsible for much life threatening diseases like Toxic-shock syndrome, staphylococcal scarlet fever, meningitis, osteomyelitis, etc. This antibiotic resistance strain, lead to development of the new antibiotics or drug molecules which can kill or suppress the growth of Staphylococcus aureus. We have performed an insilico comparative analysis of metabolic pathways of the host Homo sapiens and the pathogen S. aureus. The e-value threshold cut-off was set to 0.005. We have identifi ed total 235 enzyme sequences, which are non homologous to Homo sapiens protein sequences and among t.. Read More»
  DOI: 10.4172/jcsb.1000058

  Abstract PDF