Journal of Cytology & Histology

Rahman M Hafizur

Publications

• Research Article
  Modulation of Pancreatic �Ž�²-Cells and Antioxidant Status by Cinnamon in Type 2 Diabetic Rats
  Author(s): Noor Fatima, Areeba Khaleeq, Shahrukh Momin, Rizwana S Waraich, Saima Khaliq and Rahman M HafizurNoor Fatima, Areeba Khaleeq, Shahrukh Momin, Rizwana S Waraich, Saima Khaliq and Rahman M Hafizur
  
  The effect of Cinnamomum cassia was investigated in a non-obese type 2 diabetic rat model to explore possible cellular mechanism(s) of its antidiabetic activity. Non-obese type 2 diabetes was developed in rats by injecting 60 mg/kg streptozotocin (STZ) along with 120 mg/kg nicotinamide (NA) in adult Wistar rats. Type 2 diabetes was confirmed after 14 days of STZ-NA induction. Diabetic rats were treated with cinnamon extract at 250 mg/kg (Cn250) or 500 mg/kg dose (Cn500) and the positive control, glibenclamide (5 mg/kg) for 28 days. After treatment, blood glucose, serum insulin, HbA1c and antioxidant status were measured. Additionally, insulin and glucagon immunostaining was performed in pancreatic sections. Moderate hyperglycemia and β-cells dysfunction was found in this diabetic model rats. Interestingly, cinnamon extract treatment lowered the elevated blood glucose (Cn250: 269... Read More»
  DOI: 10.4172/2157-7099.1000477

  Abstract PDF