Journal of Bioanalysis & Biomedicine

Raju Prasad

Publications

• Research Article
  Effect of Mastitis on Pharmacokinetics of Levofloxacin Following Single Dose Intravenous Administration in Goats
  Author(s): Mahendra Ram, Vishakha Singh, Birendra Kumar Roy, Raju Prasad and Kaushal Kumar SinghMahendra Ram, Vishakha Singh, Birendra Kumar Roy, Raju Prasad and Kaushal Kumar Singh
  
  Disposition kinetics of levofloxacin was investigated after single dose intravenous administration at the dose of 10 mg/kg in six healthy and six mastitic Black Bengal lactating goats. Mastitis was induced in goats by coagulase positive Staphylococcus aureus . The maximum milk concentration was higher in mastitic goats (17.01 ± 0.67 μg/ ml) as compared to healthy (14.75 ± 0.95 μg/ml). The therapeutic milk concentration in mastitic goats (0.10 ± 0.00 to 16.61 ± 0.70 μg/ml) was maintained for 48 h, which was significantly longer than healthy goats (36 h). The t ½ β in plasma (5.08 ± 0.18 h) and milk (7.28 ± 0.09 h) of mastitic goats were significantly longer than healthy goats (4.04 ± 0.24 and 4.16 ± 0.76 h). The total body clearence in plasma of healthy goats (5.64 ± 0.78 ml/kg/min) was almost sim.. Read More»
  DOI: 10.4172/1948-593X.1000048

  Abstract PDF