Medicinal Chemistry

Raju Suresh Kumar

Publications

• Research Article
  Design, Synthesis and Antimycobacterial Activity of Dispiropyrrolidines Derivatives
  Author(s): Mohd Zaheen Hassan, Mohamed Ashraf Ali, Hasnah Osman, Raju Suresh Kumar and Natarajan ArumugamMohd Zaheen Hassan, Mohamed Ashraf Ali, Hasnah Osman, Raju Suresh Kumar and Natarajan Arumugam
  
  In vitro anti-mycobacterial activities of dispiropyrrolidine derivatives along with their intermediates bisarylidene piperidones were investigated through high throughput screen. Our results revealed that dispiropyrrolidines possess promising activity against Mtb H37Rv. Compound 4g, 1-Methyl-4-(2,4-dichlorophenyl)pyrrolo-(spiro[2.3″]oxindole)- spiro[3.3′]-5′-(2,4-dichlorophenylmethylidene)piperidin-4′-one emerged as the most active antimycobacterial agent having EC50 of 2.46 μM and MIC at 10 μM against MTB-H37Rv. .. Read More»
  DOI: 10.4172/2161-0444.1000387

  Abstract PDF