Journal of Computer Science & Systems Biology

Rama Pande

Publications

• Research Article
  Molecular -Docking Studies of Potent Anticancer Agent
  Author(s): Heena V Sanghani, Sunil H Ganatra and Rama PandeHeena V Sanghani, Sunil H Ganatra and Rama Pande
  
  Cyclin dependent kinases are critical molecules that control cell cycle progression from one phase to the other. However, mutational changes in these molecules lead to the purturbed cell cycle leading to uncontrolled cellular proliferation or cell death. In humans, mutations in cyclin dependent kinase 2 (1GII) is responsible for nearly 50% of cancers. In this paper preliminary in-silico screening were performed of natural polytriterpene phytochemical that are thought to have potential to inhibit mutated 1GII. Out of the two triterpenes boswellic acid and ursolic acid, boswellic acid shows inhibition activity with 1GII. From this study we propose that boswellic acid is promising towards oral cancer than ursolic acid... Read More»
  DOI: 10.4172/jcsb.1000085

  Abstract PDF