Journal of Nanosciences: Current Research

Raman SK

Publications

• Research Article
  In vitro Antifungal Activity of a Novel Allylamine Antifungal Nanoemulsion Gel.
  Author(s): Veera Venkata Satyanarayana Reddy Karri, Raman SK, Kuppusamy G, Sanapalli BKR, Wadhwani A, Patel V and Malayandi RVeera Venkata Satyanarayana Reddy Karri, Raman SK, Kuppusamy G, Sanapalli BKR, Wadhwani A, Patel V and Malayandi R
  
  Terbinafine HCl (TBH) is a broad spectrum antifungal agent used against dimorphic fungi, yeast, molds, dematiaceous fungi and dermatophytes. However, the poor solubility of this potential molecule renders it efficacy limited. So, the combinations of oral and topical doses are prescribed. Hence, the aim of the current study was to increase the solubility of TBH by incorporating into Nanoemulsion gel (NEG) and to investigate it’s in vitro antifungal activity using Candida albicans as a fungal inoculum. The TBH nanoemulsion was prepared using high speed homogenization technique and evaluated for its micromeritcs. The particles results revealed that acceptable globule size of 11.47 nm with a PDI of 0.556. The obtained nanoemulsion was converted in to NEG and evaluated for in vitro permeation and in vitro antifungal activity. The permeation studies reveled that NEG (76.23 ± 2.81.. Read More»
  DOI: 10.4172/2572-0813.1000119

  Abstract PDF