Journal of Cytology & Histology

Rania Ebrahim Eldesoky

Publications

• Research Article
  The Blood Cells Ultrastructure Electron Microscopy Changes: Reflection on Systemic Lupus Erythematosus
  Author(s): Eman Mohamed Faruk, Rania Ebrahim Eldesoky, Marwa Yahia Mahgoub, Enas Mohamed Mahmoud El.gndy and Hanan FouadEman Mohamed Faruk, Rania Ebrahim Eldesoky, Marwa Yahia Mahgoub, Enas Mohamed Mahmoud El.gndy and Hanan Fouad
  
  The sub-laboratory effects of SLE on blood cells were not completely evaluated to explain the thrombotic tendency found in this disease. The present study was conducted to assess the ultrastructural changes of RBCs, WBCs and platelets in SLE and to corelate these changes with the disease activity. Comet assay and 8- hydroxydeoguanosine (8-OHdG) were used to confirm cellular dysfunction. Ninety subjects were recruited and equally divided into 3 groups: Group Ι; SLE (normal CBC), Group ΙΙ; SLE (abnormal CBC) and Group ΙΙΙ; healthy control. Disease activity was evaluated by systemic lupus erythematosus disease activity index score (SLEDAI). Ultrastructure examination of blood cells were done by electron microscope, DNA damage was assessed by Comet assay and serum 8-OHdG levels. CBC and serological tests including serum C3, C4, ANA and anti-dsDNA were evaluat.. Read More»
  DOI: 10.4172/2157-7099.1000534

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