Journal of Bioanalysis & Biomedicine

Raria S. Meliala

Publications

• Research Article
  Comparative Bioavailability Study of Two Ramipril Tablet Formulations in Indonesian Healthy Volunteers
  Author(s): Yahdiana Harahap, Lucy Sasongko, Budi Prasaja, Windy Lusthom, Evy C. Setiawan, Raria S. Meliala and LipinYahdiana Harahap, Lucy Sasongko, Budi Prasaja, Windy Lusthom, Evy C. Setiawan, Raria S. Meliala and Lipin
  
  Aim To compare the bioavailability of two ramipril tabl et for- mulations – 10 mg Prohytens ® tablets as test formulation and 10 mg Triatec ® tablets as reference formulation. Methods A single-dosed, open-label, randomized two-way cros s- over design under fasting period with two weeks was h out period was evaluated in 24 subjects. For the an alysis of pharmacokinetic properties, the blood samples we re drawn taken up to 72 hours after dosing. Plasma con cen- tration of ramipril and ramiprilat were determined using liquid chromatography – tandem mass spectrometry method with TurboIonSpray mode. Pharmacokinetic pa- r a meter s AUC 0 -t, AUC 0- ∞ a nd C max wer e tes ted for bioequivalence after log-transform.. Read More»
  DOI: 10.4172/1948-593X.1000004

  Abstract PDF