Molecular Biomarkers & Diagnosis

Rasha A Al Din

Publications

• Research Article
  Interleukin 23 P 19 Expression in Patients with Ulcerative Colitis and Its Relation to Disease Severity
  Author(s): Hanan El-Bassat, Lobna Abo Ali, Sahar El Yamany, Hanan Al Shenawy, Rasha A Al Din and Atef TahaHanan El-Bassat, Lobna Abo Ali, Sahar El Yamany, Hanan Al Shenawy, Rasha A Al Din and Atef Taha
  
  Background and study aims: The purpose of this study is to determine whether mucosal expression of IL 23 p 19 has role in the pathogenesis of ulcerative colitis and its relation to disease severity. Materials and methods: This study was carried out on 50 patients with ulcerative colitis and 10 normal individuals as control. They were divided into: Group I: 27 patients with mild to moderate disease. Group II: 23 patients with severe disease. Group III: 10 normal individuals. All patients and control were subjected to histopathological study, IL-23p19 immunohistochemical staining, IL-23R expression by flow cytometry and serum IL-23 by ELISA. Results: There is significant increased in IL-23p19 gene and IL-23R in ulcerative colitis patients compared with control. Significant positive correlation was detected between in.. Read More»
  DOI: 10.4172/2155-9929.1000191

  Abstract PDF