Journal of Bioanalysis & Biomedicine

Ratendra K Chaudhary

Publications

• Research Article
  High-performance Liquid Chromatographic Method with Diode Array Detection for Quantification of Haloperidol Levels in Schizophrenic Patients During Routine Clinical Practice
  Author(s): Tarun Jain, Anil Bhandari, Veerma Ram, Sanjay Sharma, Ratendra K Chaudhary and Manish ParakhTarun Jain, Anil Bhandari, Veerma Ram, Sanjay Sharma, Ratendra K Chaudhary and Manish Parakh
  
  Rationale: Till date, very few HPLC methods are available with short run time for monitoring of haloperidol, facilitating large number of sample analysis within short time frame. Objective: A selective and sensitive reverse phase high-performance liquid chromatographic assay has been developed for monitoring of Haloperidol levels. Methodology: Chromatogram separation of Haloperidol and Loratidine (Internal Standard) was achieved using C18 column as stationary phase. Mobile phase consists of Acetonitrile and Water (50:50), pH-2.5 with 0.1% Acetic Acid and 0.05 M KHPO4 at a flow rate of 1.6 mL min-1. Detection was carried out at 240 nm using UV-PDA detector. Retention time for Haloperidol and Internal Standard was found to be 2:13 and 3:16 minutes respectively. The method has bee.. Read More»
  DOI: 10.4172/1948-593X.1000037

  Abstract PDF