Pulmonary & Respiratory Medicine

Ravi Kr Gupta

Publications

• Research Article
  Defining New Drug Targets Through Protein-Protein Interaction: Interaction of Resuscitation Promoting Factors with SucA of TCA Cycle in M. tuberculosis H37Rv
  Author(s): Ravi Kr Gupta, Swati Srivastava, Brahm S Srivastava and Ranjana SrivastavaRavi Kr Gupta, Swati Srivastava, Brahm S Srivastava and Ranjana Srivastava
  
  Upon infection with Mycobacterium tuberculosis, only a small percentage causes active infection while the rest goes into latent infection. These latent bacilli can reactivate under immunocompromised conditions and cause active disease. Little is known about the mechanism by which the mycobacteria reactivate. A family of extracellular bacterial proteins, known as resuscitation promoting factors (Rpf) from Micrococcus luteus and M. tuberculosis has been shown to stimulate growth of dormant mycobacteria as well as reactivation of chronic tuberculosis in mice. Rpf is present as a single, essential gene in M. luteus and five homologues (rpfA-E) in M. tuberculosis. The ability to stimulate culturability and resuscitation appears to be related to muralytic activity of Rpf and they have been identified as peptidoglycan glycosidases. Rpf B has earlier been sh.. Read More»
  DOI: 10.4172/2161-105X.1000363

  Abstract PDF