Cardiovascular Diseases & Diagnosis

Regis Bobe

Publications

• Review Article
  Sarco (Endo) Plasmic Reticulum Calcium Atpases (SERCA) Isoforms in the Normal and Diseased Cardiac, Vascular and Skeletal Muscle
  Author(s): Elie R Chemaly, Regis Bobe, Serge Adnot, Roger J Hajjar and Larissa LipskaiaElie R Chemaly, Regis Bobe, Serge Adnot, Roger J Hajjar and Larissa Lipskaia
  
  Deregulated or enhanced calcium ion (Ca2+) influx across an unstable sarcolemma has been proposed to directly affect cardiac hypertrophic remodelling, vascular proliferative diseases and degenerative muscle disorders. Aberrant intracellular handling is partly due to a defect in Sarcoplasmic Reticulum (SR) function. Decreased Ca2+ uptake in cardiac, vascular and skeletal myocytes is associated with a decrease in the expression and activity of the fast sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a or SERCA1a isoforms). SERCA2a gene transfer was successfully used in heart failure; this approach holds further therapeutic promises in vascular proliferative diseases and dystrophin-deficient muscular diseases. The growing family of human SERCA isoforms comprises at least 14 mRNA and proteins with different functional characteristics and cell-specific expression. This review focuses on the.. Read More»
  DOI: 10.4172/2329-9517.1000113

  Abstract PDF