Medical Microbiology & Diagnosis

Rekha Bhadauria

Publications

• Research Article
  Expansion of T regulatory Cells in Lepromatous Leprosy is Mediated by Phenolic Glycolipid-1
  Author(s): Bhavyata Dua, Bhawna Sharma, Joy Kumar Chakma, Mamta Arora, Rekha Bhadauria, Dipendra Kumar Mitra and Beenu JoshiBhavyata Dua, Bhawna Sharma, Joy Kumar Chakma, Mamta Arora, Rekha Bhadauria, Dipendra Kumar Mitra and Beenu Joshi
  
  In leprosy, lepromatous form of the disease is more severe and results from suppression of T cell response. T regulatory cells which suppress T cell response has been found in higher frequency in blood and at the site of infection in leprosy. Therefore, present study was carried out to evaluate the role of Mycobacterium leprae antigens whole cell sonicate (WCS) and especially phenolic glycolipid-1 (PGL-1), which is known for its suppressive nature, in the induction of T regulatory cells expansion in peripheral blood of leprosy patients. For this purpose peripheral blood mononuclear cells (PBMCs) of different category of leprosy patients and healthy controls were stimulated with M. leprae antigens in vitro and percentage of T regulatory cells was determined by flow cytometry. We found higher frequency of T regulatory cells in PBMCs of untreated borderline lepromatous/lepromatous lepros.. Read More»
  DOI: 10.4172/2161-0703.1000226

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