Medicinal Chemistry

Renata Barbieri

Publications

• Research Article
  DNA Damage and Cell Death Induced by Crude Extract of the Orchid Oncidium flexuosum Sims
  Author(s): Mônica Piacentini Luizon, Caroline Santos Oliveira, Danielly Kathe Zaqueo, Jaqueline Aparecida Oliveira, Gustavo Ligieri Pereira do Prado, Renata Barbieri, Fernanda Oliveira Gaspari de Gaspi, João Ernesto de Carvalho, Elaine Cristina Mathias da Silva-Zacarin, Camila Andréa Oliveira, Acácio Antônio Pigoso and Grasiela Dias de Campos Severi-AguiarMônica Piacentini Luizon, Caroline Santos Oliveira, Danielly Kathe Zaqueo, Jaqueline Aparecida Oliveira, Gustavo Ligieri Pereira do Prado, Renata Barbieri, Fernanda Oliveira Gaspari de Gaspi, João Ernesto de Carvalho, Elaine Cristina Mathias da Silva-Zacarin, Camila Andréa Oliveira, Acácio Antônio Pigoso and Grasiela Dias de Campos Severi-Aguiar
  
  Oncidium flexuosum Sims. is an orchidwhose leaves are frequently used for therapeutic applications although its action mechanism is not exactly understood. So the aim of this study was investigate its effects in Wistar rat liver, kidney and bone marrow. For this purpose, twenty-five adult male Wistar rats were divided into five groups of 5 animals each: a control group receiving only water, a positive control receiving a mutagen compound and three groups treated for 15 days with 100, 250 or 500 mg/kg/day of a crude hydroalcoholic leaf extract of O. flexusosum Sims. No significant alterations were observed in –SH groups, MDA or catalase, showing that the extract does not induce hepatic oxidative damage. There was no evidence of kidney injury and hepatic function alteration (ALT). However, significant mitochondrial swelling was observed in the tre.. Read More»
  DOI: 10.4172/2161-0444.1000147

  Abstract PDF