Medicinal Chemistry

Renata da Silva Zardo

Publications

• Research Article
  Synthesis, Antiproliferative and Anti-inflammatory Activities of Novel Simplified Imatinib Analogues
  Author(s): Thiago Stevanatto Sampaio, Lídia Moreira Lima, Renata da Silva Zardo, Cláudia Pessoa, Bruno Coêlho Cavalcanti, Rosane de Paula Castro, José Ricardo Sabino, Patrícia Dias Fernandes and Eliezer J BarreiroThiago Stevanatto Sampaio, Lídia Moreira Lima, Renata da Silva Zardo, Cláudia Pessoa, Bruno Coêlho Cavalcanti, Rosane de Paula Castro, José Ricardo Sabino, Patrícia Dias Fernandes and Eliezer J Barreiro
  
  We described the synthesis of carboxamide derivatives designed as novel simplified imatinib analogues and their antiproliferative and anti-inflammatory activities. Compound 2c showed a unique conformation determined by X-ray diffraction and by NMR 1H and displayed antiproliferative potency in the same magnitude order than the standard imatinib. Compounds 6-10 were prepared by structural modification in carboxamide 2c, and with exception of derivative 10, they were inactive as antiproliferative agent. However, these compounds showed same anti-inflammatory potency than imatinib, standing out carboxamide 9 that was six time more potent as TNF-α inhibitor production. .. Read More»
  DOI: 10.4172/2161-0444.1000226

  Abstract PDF