Journal of Bioanalysis & Biomedicine

Reynal L VanGilder

Publications

• Research Article
  Systemic Transcriptional Alterations of Innate and Adaptive Immune Signaling Pathways in Atherosclerosis, Ischemia Stroke, and Myocardial Infarction
  Author(s): Taura L Barr, Reynal L VanGilder, Ryan Seiberg, Ashely Petrone, Paul D Chantler and Chiang-Ching HuangTaura L Barr, Reynal L VanGilder, Ryan Seiberg, Ashely Petrone, Paul D Chantler and Chiang-Ching Huang
  
  Background: Transcriptional profiles are available for a variety of cardiovascular-related diseases. The goal of this study was to compare blood transcriptional profiles of the Toll-like receptor (TLR), T-cell receptor (TCR), and B-cell receptor (BCR) signaling pathways in asymptomatic atherosclerosis, acute ischemic stroke, and myocardial infarction patients to identify common mechanisms of immune regulation and their association with epigenetic regulation. Methods and results: Peripheral blood gene expression profiles from human atherosclerosis-related diseases and healthy controls were downloaded from Gene Expression Omnibus (GEO). Genes in the TLR, TCR, and BCR pathways were retrieved from the NCBI BioSystems database. Significance of gene enrichment and concordance of expression ch.. Read More»
  DOI: 10.4172/1948-593X.1000120

  Abstract PDF