Journal of Spine

Reza Vazifehmand

Publications

• Review Article
  MicroRNA Based Therapy and Osteoporosis: A Review of a Novel Therapeutic Agent from Diagnosis to Treatment
  Author(s): Tina Saber, Dhuha Saeed Ali, Foroozandeh monem homaie and Reza VazifehmandTina Saber, Dhuha Saeed Ali, Foroozandeh monem homaie and Reza Vazifehmand
  
  Disequilibrium between bone resorption and bone formation may cause osteoporosis that reduces bone integrity and physiological function of skeletal system. Osteoblast and osteoclast genesis are two major of biological events that act in bone turnover and dynamic rate of bone remodeling. Ample evidences have been revealed that RANK-L/ OPG, Wnt and BMP Pathways are crucial pathways involved in osteoporosis. Treatment of osteoporosis is becoming important task in post menopause women and old people. Current treatment strategies with osteoporosis drugs are mainly by inhibiting the bone-resorbtion. However, these synthetic medicines have limitless side effects. Several studies have established the important of a group of small non-coding RNAs (MiRNAs) which involve in pathogenesis osteoporosis, bone remodeling, osteoblast differentiation and osteoclast formation and has consider as a gold .. Read More»
  DOI: 10.4172/2165-7939.1000416

  Abstract PDF