Molecular Biomarkers & Diagnosis

Rezvan Mirzaei

Publications

• Research Article
  Correlation among MDR1, MRP and hTERT Genes Expression Level and Clinical Response in Colorectal Cancer Patients
  Author(s): Samira Shabani, Sara Samanian, Rezvan Mirzaei, Bahar Mahjoubi and Frouzandeh MahjoubiSamira Shabani, Sara Samanian, Rezvan Mirzaei, Bahar Mahjoubi and Frouzandeh Mahjoubi
  
  Introduction: Colon cancer is one of the common cancers in the world. Despite current advances in the treatments of cancer, the clinical result is far away from expectation yet. Drug resistance is still a major obstacle in treatment of cancer .In this study, we attempted to investigate the possible correlation among MRP1, MRP and hTERT expression level and multidrug resistance in colon cancer patients. Materials and Methods: Tumor and adjacent normal tissues from 35 colorectal cancer patients were assessed for the mRNA expression level of MDR1, MRP and hTERT by Real Time RT-PCR. Results: A statistically significant increase in MDR1 and hTERT expression level was observed in tumoral tissues in comparison with normal tissues. However MRP expression level was not significantly increased in tumoral tissues. Furthermore.. Read More»
  DOI: 10.4172/2155-9929.1000187

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