Transplantation Technologies & Research

Riccardo Saccardi

Publications

• Research Article
  Mesenchymal Stem Cell-Based Immunomodulation in Allogeneic Heterotopic Heart-Lung Transplantation
  Author(s): Biancamaria Longoni, Erzsèbet Szilàgyi, Lorenza Puviani, Benedetta Mazzanti, Giacomo Timoteo Paoli, Serena Urbani, Paola Quaranta, Sara Antonini, Sergio Tripodi, Marcella Cintorino, Riccardo Saccardi, Bruno Nardo and Franco MoscaBiancamaria Longoni, Erzsèbet Szilàgyi, Lorenza Puviani, Benedetta Mazzanti, Giacomo Timoteo Paoli, Serena Urbani, Paola Quaranta, Sara Antonini, Sergio Tripodi, Marcella Cintorino, Riccardo Saccardi, Bruno Nardo and Franco Mosca
  
  Mesenchymal stem cells are able to differentiate in various cell lineages and they have shown immunomodulatory properties in vitro, altering the cytokine secretion profile of T helper, T effector and dendritic cells and stimulating natural killer cells towards an anti-inflammatory and tolerant phenotype. In vivo they prolong skin allograft survival and may decrease graft-versus-host disease after hematopoietic stem cell transplants. In this work we studied the effects of mesenchymal stem cell treatment in an allogeneic heterotopic heart-lung transplant model. The following experimental groups were formed: A) Control B) Immunosuppressive therapy (Cyclosporine A) C) Mesenchymal stem-cell intravenous infusion D) Mesenchymal stem-cell infusion plus immunosuppressive treatment. The infusion of mesenchymal stem cells improved the mean graft survival up to 14.5±.. Read More»
  DOI: 10.4172/2161-0991.1000107

  Abstract PDF