Molecular Biomarkers & Diagnosis

Richard D Beger

Publications

• Research Article
  Systems Biology Investigation to Discover Metabolic Biomarkers of Acetaminophen-Induced Hepatic Injury Using Integrated Transcriptomics and Metabolomics
  Author(s): Jinchun Sun, Yosuke Ando, Dörthe Ahlbory-Dieker, Laura K Schnackenberg, Xi Yang, James Greenhaw, Lisa Pence, Feng Qian, William Salminen, Donna L Mendrick and Richard D BegerJinchun Sun, Yosuke Ando, Dörthe Ahlbory-Dieker, Laura K Schnackenberg, Xi Yang, James Greenhaw, Lisa Pence, Feng Qian, William Salminen, Donna L Mendrick and Richard D Beger
  
  Background: Drug-induced hepatotoxicity is one of the major reasons for drug recall and hence it is of major concern to the FDA and consumers. Overdose of acetaminophen (APAP) can cause acute hepatic injury. The current clinical biomarkers of liver injury are insufficient in predicting the extent of injury; thus novel biomarkers are needed to integrate with the current biomarkers for better risk assessment during drug development and clinical use. Methods: Sprague-Dawley rats were orally gavaged with a single dose of 0.5% methylcellulose (control), 100 mg APAP/kg body weight or 1250 mg APAP/kg body weight. Urine, terminal blood samples and tissues were collected at 6, 24, 72, and 168 h for clinical chemistry and histopathology analyses. Based on the clinical chemistry data and histopathology, liver injury occurred in treated animals during t.. Read More»
  DOI: 10.4172/2155-9929.S1-002

  Abstract PDF