Journal of AIDS & Clinical Research

Richard J. Jurevic

Publications

• Research Article
  Copy Number Variation within Human β-Defensin Gene Cluster Influences Progression to AIDS in the Multicenter AIDS Cohort Study
  Author(s): Rajeev K. Mehlotra, Jean-Eudes Dazard, Bangan John, Peter A. Zimmerman, Aaron Weinberg and Richard J. JurevicRajeev K. Mehlotra, Jean-Eudes Dazard, Bangan John, Peter A. Zimmerman, Aaron Weinberg and Richard J. Jurevic
  
  Study background: DEFB4/103A encoding β-defensin 2 and 3, respectively, inhibit CXCR4-tropic (X4) viruses in vitro. We determined whether DEFB4/103A Copy Number Variation (CNV) influences time-to-X4 and time-to-AIDS outcomes. Methods: We utilized samples from a previously published Multicenter AIDS Cohort Study (MACS), which provides longitudinal account of viral tropism in relation to the full spectrum of rates of disease progression. Using traditional models for time-to-event analysis, we investigated association between DEFB4/103A CNV and the two outcomes, and interaction between DEFB4/103A CNV and disease progression groups, Fast and Slow. Results: Time-to-X4 and time-to-AIDS were weakly correlated. There was a stronger relationship between these two outcomes for the fast progressors. DEFB4/103A CNV was associated with time-to-AIDS, but not time-to-X4. The association between.. Read More»
  DOI: 10.4172/2155-6113.1000184

  Abstract PDF