Pulmonary & Respiratory Medicine

Rishi Sharma

Publications

• Review Article
  The Role of Macrolides in Unified Airway Disease (UAD) A Review
  Author(s): Adam C Gaunt, Rishi Sharma and Sally ErskineAdam C Gaunt, Rishi Sharma and Sally Erskine
  
  Unified Airways Disease (UAD) encompasses distinct clinical entities including chronic rhinosinusitis and asthma and gives credence to the hypothesis that these are different facets of the same disease process. Macrolide antibiotics are derived from the prototypic macrolide erythromycin. This was discovered in the early 1950’s as an isolate from the soil bacteria Saccharopolyspora erythraea and it is known to be a primarily bacteriostatic agent. Macrolides are a commonly used class of antibiotic that are known to have actions beyond their primary bactericidal functions and have been shown to be of benefit in conditions affecting all constituents of the airway, including chronic rhinosinusitis, asthma, diffuse panbronchiolitis and cystic fibrosis. These properties include potent anti-inflammatory and immunomodulatory effects. Pro.. Read More»
  DOI: 10.4172/2161-105X.1000312

  Abstract PDF