Journal of Bioengineering & Biomedical Science

Rizik L

Publications

• Research Article
  Noise Tolerance Analysis for Reliable Analog and Digital Computation in Living Cells
  Author(s): Rizik L, Ram Y and Danial RRizik L, Ram Y and Danial R
  
  Biomolecular computing, encompassing computations performed by molecules, proteins and DNA, is a central area of focus in Synthetic Biology research and development, which attempt to apply engineering design principles in living cells. Two major computation paradigms have been implemented so far in living cells - analog paradigm that computes with a continuous set of numbers and digital paradigm that computes with two-discreet set of numbers. Here, we analyze the biophysical and technological limits of large-scale gene networks created based on analog and digital computation in living cells. More specifically, we calculate the precision of analog systems and the noise margin of digital systems in living cells. We conclude that both systems are challenging to operate with low protein levels. To overcome this challenge, we show that analog systems should operate with a Hill coefficient .. Read More»
  DOI: 10.4172/2155-9538.1000186

  Abstract PDF