Vitamins & Minerals

Robert C. Hider

Publications

• Research Article
  Combination Treatments of 1-(N-Acetyl-6-Aminohexyl)-3-Hydroxy-2- Methylpyridin-4-One (CM1) With Deferiprone and Desferrioxamine Reduced Labile Iron Pool and Protected Oxidative Stress in Iron-Loaded Cultured Hepatocytes
  Author(s): Kanokwan Kulprachakarn, Kanjana Pangjit, Chada Phisalaphong, Suthat Fucharoen, Robert C. Hider and Somdet SrichairatanakoolKanokwan Kulprachakarn, Kanjana Pangjit, Chada Phisalaphong, Suthat Fucharoen, Robert C. Hider and Somdet Srichairatanakool
  
  Iron overload associated with oxidative stress is a serious problem in transfusion-dependent patients with β-thalassemia major. The increased iron overload in several organs may be caused by higher intestinal absorption along with less intensive chelation therapy. Liver iron overload could in turn facilitate the development or persistence of chronic progressive liver disease. Previous studies have shown that chelation with desferrioxamine (DFO) and deferiprone (DFP) substantially reduced body-iron scores in β-thalassemia patients with transfusional iron overload. We have synthesized and characterized a new bidentate iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2- methylpyridin-4-one (CM1). The compound can efficiently scavenge iron from both ferrous and ferric salts and plasma non-transferrin bound iron (NTBI). In this study we have studied the efficacy of the CM1 trea.. Read More»
  DOI: 10.4172/vms.1000115

  Abstract PDF