Journal of Spine

Roberta Ramonda

Publications

• Case Report
  Ankylosing Spondylitis in Association with Non-Hodgkin's Lymphoma : Successful Anti-TNF Alpha Treatment
  Author(s): Augusta Ortolan, Anna La Salvia, Mariagrazia Lorenzin, Paola Frallonardo, Dario Marino, Leonardo Punzi and Roberta RamondaAugusta Ortolan, Anna La Salvia, Mariagrazia Lorenzin, Paola Frallonardo, Dario Marino, Leonardo Punzi and Roberta Ramonda
  
  Some rheumatic diseases, including ankylosing spondylitis, appear to be associated to an increased risk of cancer, in particular lymphoma. At the same time, a slightly higher risk of cancer has been associated to Tumour Necrosis Factor (TNF)-alpha antagonists, a widely used treatment for ankylosing spondylitis. A history of malignancy is generally considered a contraindication to TNF-alpha inhibitor and, if neoplasia is uncovered during treatment, therapy suspension is mandatory. Few data are available regarding the possibility of resuming treatment in the event of a flare up of this disease, even when exams monitoring the neoplastic disease are negative. Here we describe the case of a 56-year-old AS patient who developed a cutaneous B-cell non-Hodgkin lymphoma while undergoing treatment with a TNF-alpha inhibitor. The therapy was suspended while he was treated for the neoplasia, but .. Read More»
  DOI: 10.4172/2165-7939.1000272

  Abstract PDF