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Transplantation Technologies & Research

ISSN: 2161-0991

Open Access

Roberta Rizzo

Section of Microbiology and Medical Genetics,
Via Luigi Borsari, 46, I-44121 Ferrara
Italy

Publications
  • Editorial
    Immunosupressive Properties of HLA-G Molecules Produced by Mesenchymal Stromal Cells
    Author(s): Roberta RizzoRoberta Rizzo

    The main interest in human mesenchymal stromal cells (hMSCs) is correlated with their ability to suppress the proliferation of immune cells and to regulate the transplantation rejection. The mechanisms at the basis of MSCs activity need cell-cell interaction and the expression of molecules induced by the micro-environment. The inhibitory functions of MSCs involve several molecules as hepatocyte growth factor, transforming growth factor-beta (TGF-beta), interleukin-10 and -2 (IL-10, IL-2), tumour necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), indoleamine 2,3-dioxygenase (IDO), and HLA-G antigens. A large consesus has been obtained on the immune-modulatory role of HLA-G molecules produced by hMSCs... Read More»
    DOI: 10.4172/2161-0991.1000e127

    Abstract PDF

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Citations: 223

Transplantation Technologies & Research received 223 citations as per Google Scholar report

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