Molecular Biomarkers & Diagnosis

Robin PF Dullaart

Publications

• Research Article
  Plasma apoE is Elevated in Metabolic Syndrome: Importance of Large Very Low Density and Low Density Lipoprotein Particles
  Author(s): Eke G Gruppen, Geesje M Dallinga- Thie, Stephan JL Bakker and Robin PF DullaartEke G Gruppen, Geesje M Dallinga- Thie, Stephan JL Bakker and Robin PF Dullaart
  
  Background: Apolipoprotein E (apoE) is carried by all major lipoprotein classes in plasma and is likely to contribute to the development of atherosclerosis. We set out to determine the extent to which plasma apoE is related to various VLDL, LDL and HDL subfractions in subjects with and without metabolic syndrome (MetS). Methods: Plasma lipids, lipoprotein subfractions (nuclear magnetic resonance spectroscopy) and plasma apoE were determined in 60 subjects with and 62 subjects without MetS (APOE ε2/ε2 carriers excluded). Results: Plasma apoE was higher in MetS, coinciding with increased total and large VLDL particles, as well as total LDL particles (p<0.01 for each after age, sex and diabetes status adjustment). Age- and sex-adjusted multivariable linear regression analysis revealed that plasma apoE was rel.. Read More»
  DOI: 10.4172/2155-9929.1000210

  Abstract PDF