Medicinal Chemistry

Rodolfo Toledo Filgueiras

Publications

• Research Article
  High Anti-Inflammatory Activity and Low Toxicity of Thalidomide Analogs
  Author(s): Victor Soares Cavalcante Costa, Rodolfo Toledo Filgueiras, Bárbara Bruna Muniz Figueiredo, Luciano Mazzoccoli, Silvia Helena Cardoso, Maria Christina Marques Nogueira Castanon, Giovanni Wilson Amarante, Mauro Vieira de Almeida, Nádia Resende Barbosa Raposo and Henrique Couto TeixeiraVictor Soares Cavalcante Costa, Rodolfo Toledo Filgueiras, Bárbara Bruna Muniz Figueiredo, Luciano Mazzoccoli, Silvia Helena Cardoso, Maria Christina Marques Nogueira Castanon, Giovanni Wilson Amarante, Mauro Vieira de Almeida, Nádia Resende Barbosa Raposo and Henrique Couto Teixeira
  
  Thalidomide is an immunomodulatoryagent with anti-inflammatory activity, however it may also cause serious side effects. New compounds derived from thalidomide effective in modulating inflammatory responses and having an improved safety profile is being investigated. In this study, two thalidomide analogs, GI-16 and SC-15, were evaluated using the carrageenan-induced paw swelling and the lipopolysaccharide (LPS)-induced lung inflammation in mice. Acute and sub-chronic toxicity of the compounds were investigated in blood and serum samples of Wistar rats by measurements of hematological and biochemical parameters. Histopathological analyses were conducted to assess inflammatory cell infiltration in heart, liver and kidneys. Our results show that treatment with GI-16 and SC-15 reduced the carrageenan-induced paw edema over a 24 hour period. GI-16 and SC-.. Read More»
  DOI: 10.4172/2161-0444.1000282

  Abstract PDF