Molecular Biomarkers & Diagnosis

Rosalia D’Angelo

Publications

• Research Article
  PON I and GLO I Gene Polymorphisms and Their Association with Breast Cancer: A Case-Control Study in a Population from Southern Italy
  Author(s): Carmela Rinaldi, Rosalia D’Angelo, Alessia Ruggeri, Marco Calabro, Concetta Scimone and Antonina SidotiCarmela Rinaldi, Rosalia D’Angelo, Alessia Ruggeri, Marco Calabro, Concetta Scimone and Antonina Sidoti
  
  Background: Many factors may play a role in the susceptibility to the breast cancer. Oxidative stress may be one of these. Polymorphisms of genes such as paraoxonase I (PON I) and glyoxalase I (GLO I) may influence individual susceptibility to breast cancer. In the present study, we have conducted a case-control study in order to examine the possible relation between GLO I A111E and PON I Q192R/L55M polymorphisms with the risk of breast cancer. Methods: The three polymorphisms were characterized in 144 breast cancer postmenopausal patients and in 152 healthy women by PCR/RFLP methods using DNA from lymphocytes. Results: Among the three polymorphisms, only PON I L55M polymorphism was associated with the patient’s age and, more precisely, the heterozygous genotype that is more represented in women aged between .. Read More»
  DOI: 10.4172/2155-9929.1000170

  Abstract PDF