India
Research Article
Neuroprotective Role of Quercetin against Arsenic Induced Oxidative Stress in Rat Brain
Author(s): Shveta Nirankari, Rozy Kamal and Devinder K DhawanShveta Nirankari, Rozy Kamal and Devinder K Dhawan
Arsenic, a poisonous metalloid, is ubiquitous in the environment, and affects nearly all organ systems of animals including humans. The present study was conducted to understand the protective role of quercetin, a natural flavonoid on arsenic-induced oxidative damage in rat brain. Forty male Sprague Dawley rats, aged between 7 to 8 weeks and weighing 150-200 g were divided into four groups viz. normal control, arsenic treated, quercetin treated and arsenic + quercetin treated. Rats in normal control group were given normal food and drinking water. Rats in arsenic treated group were given arsenic daily in the form of sodium arsenite (NaAsO2) in drinking water at a dose of 100 mg/l. Rats in the quercetin treated group were given quercetin, dissolved in distilled water, orally everyday through intubation gavage at a dose of 50 mg/kg body weight. Rats in the c.. Read More»
DOI:
10.4172/2161-0525.1000359
Environmental & Analytical Toxicology received 6818 citations as per Google Scholar report