Journal of Bioanalysis & Biomedicine

Ruiz-Azuara L

Publications

• Research Article
  Pharmacokinetics of Casiopeína IIgly in Beagle Dog: A Copper Based Compound with Antineoplastic Activity
  Author(s): Cañas-Alonso RC, Fuentes-Noriega I and Ruiz-Azuara LCañas-Alonso RC, Fuentes-Noriega I and Ruiz-Azuara L
  
  Casiopeína IIgly is a mixed chelate coordination complex with copper core that have demonstrated high antineoplas- tic activity in vitro and in vivo . In the present work, a de- veloped a nd va lida ted method for mea surement of Casiopeína IIgly in beagle dog and its application in a phar- macokinetic study is reported. The analyte was isolated from blood by solid-phase extraction using Strata X cartridges. The analysis was carried out on a Synergy Polar-RP col- umn (30 X 2.0 mm) using an isocratic elution and MeOH/ HFBA 0.1% (4:6) as the mobile phase. An Agilent LC/ MSD Trap VL equipped with an ionization electrospray source, was operated in selective ion storage (SIS) using stable ion [Cu (II) (F 7 C 3 COO) 4,7-dimethyl phen ] + with 484 m/z for quantification result of ESI reaction between Casiopeína IIgly and HF.. Read More»
  DOI: 10.4172/1948-593X.1000018

  Abstract PDF