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Biosensors & Bioelectronics

ISSN: 2155-6210

Open Access

Rupali Saxena


India

Publications
  • Review Article
    Recent Techniques for the Detection of β-Thalassemia: A Review
    Author(s): Gourav Mishra, Rupali Saxena, Amit Mishra and Archana TiwariGourav Mishra, Rupali Saxena, Amit Mishra and Archana Tiwari

    β-thalassemias are very heterogeneous in nature, with respect to the molecular basis of the disease. This type of disorder is caused by extensive deletions occurring within the β-globin gene locus, present on chromosome number 11. Due to point mutations, stop codons in the β-globin mRNA is introduced, thus curbing its normal function. This paper reviews conventional and latest β-thalassemia detection techniques. Amongst the conventional techniques, the DNA-based piezoelectric biosensors were based on the observation of distinguishable frequency shifts, resulting from the hybridisation between an oligonucleotide probe which was immobilized on a gold electrode of a quartz crystal and the complementary strand; present in solution. Q-primer real time PCR (Q-PCR) system utilises the 5’>3’ exonuclease activity of a DNA polymerase, which cleaves the n.. Read More»
    DOI: 10.4172/2155-6210.1000123

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