Journal of Dermatology and Dermatologic Diseases

Ryouichi Yoshikawa

Publications

• Research Article
  The Novel Therapy for Vitiligo Vulgaris: Topical Use of Cosmetic Cream of Platinum Nanoparticles and Palladium Nanoparticles Which Show Strong Catalase-like Activity
  Author(s): Takakazu Shibata, Ryouichi Yoshikawa and Masamistu IchihashiTakakazu Shibata, Ryouichi Yoshikawa and Masamistu Ichihashi
  
  Background: Vitiligo is an acquired skin disease characterized by loss of melanin pigment due to disappearance of functional melanocytes. Several treatments are recommended worldwide, but none is really effective. Topical use of materials having high catalase activity is suggested to be effective to regain melanin pigment in the vitiligo skin. Objective: To investigate the efficacy and safety of topical use of PAPLAL which has extremely high activity of catalase in the treatment of vitiligo vulgaris subjects. Methods and Patients: 58 patients with vitiligo vulgaris who suffered more than 10% skin area and were refractory to the conventional therapies during the last one year or more. PAPLAL cream containing platinum (Pt, 139 μM) and palladium (Pd, 40 μM) nanoparticles, or PAPLAL lotion (Pt:5 μM, Pd:7 μM) was topically applied two times a day at the depigmented skin, mainly.. Read More»
  DOI: 10.4172/2376-0427.1000184

  Abstract PDF