Journal of AIDS & Clinical Research

Ryszard Lec

Publications

• Research Article
  A Novel Point-of-Care BioNanoSensor for Rapid HIV Detection and Treatment Monitoring
  Author(s): Tomasz Rozmyslowicz, Johann deSa, Ryszard Lec and Glen N GaultonTomasz Rozmyslowicz, Johann deSa, Ryszard Lec and Glen N Gaulton
  
  We report here a new diagnostic approach to the direct detection of HIV in blood or other body fluids that is rapid, sensitive and potentially applicable in a point-of-care setting. The approach follows on the development of a novel BioNanoSensor (BNS) device that utilizes piezoelectric technology to detect the presence of the HIV surface glycoprotein gp120 in a nanoscale format. The detection range of the BNS device for the biomarker gp120 displayed a low-end sensitivity of 6.5×104 HIV viral particles/ml, while using a small fluid sample (5 μl) and with a reaction time of less then 30 seconds. Performance of this device indicated that the BNS has utility for direct detection of HIV particles prior to, and independent from, antibody formation. Accordingly, this device holds utility to monitor the status of HIV infection both early after expos.. Read More»
  DOI: 10.4172/2155-6113.1000454

  Abstract PDF