Journal of Computer Science & Systems Biology

S Haas

Publications

• Research Article
  Back Action on Neurotransmitters by Receptor Binding Reveals an Optimal Receptor Density Profile
  Author(s): T Albash, JMC Bouteiller, TW Berger, M Baudry and S HaasT Albash, JMC Bouteiller, TW Berger, M Baudry and S Haas
  
  We discuss how integration of back action into coupled rate equations describing dynamical biophysical processes can lead the identification of optimized structural features. This approach is applied to analyze neural receptor binding and function. In functional receptor studies, the influence of ligand binding to the receptor on free ligand concentration in the synaptic cleft is rarely considered, especially when the number of ligand molecules vastly exceeds the number of receptors. Here we evaluate the role of ligand binding/unbinding to the receptor on ligand concentration and the resulting change in receptor dynamics using the example of glutamate interaction with the AMPA receptor subtype of glutamate receptors. We find a significant difference for AMPA receptor-mediated current between the free diffusion case, where binding/unbinding is neglected, an.. Read More»
  DOI: 10.4172/0974-7230.1000129

  Abstract PDF